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. 2021 May 18;13(10):2438. doi: 10.3390/cancers13102438

Figure 3.

Figure 3

Loss of Pgrmc1 aggravates liver injury while suppressing compensatory proliferation. (A) WT and Pgrmc1-null mice were injected with high-dose DEN (200 mg/kg, i.p.), and their plasma and livers were collected after 48 h. (B) Plasma level of alanine aminotransferase (ALT). (C) Expression of high mobility group box 1 (HMGB1) in the plasma. The expression level was normalized to that of plasma albumin and expressed relative to the WT group. (D) TUNEL staining in the livers of WT and Pgrmc1-null mice. TUNEL-positive cells were counted and expressed relative to the WT group. Scale bar, 100 μm. (E) Ki67 immunostaining in the livers of WT and Pgrmc1-null mice. Ki67-positive cells were counted and expressed relative to the WT group. Scale bar, 100 μm. (F) mRNA expression levels of C-Myc, Cyclin D, and Hgf in the livers of WT and Pgrmc1-null mice. The expression level was normalized to that of Rplp0 and expressed relative to the WT group. * p < 0.05 in Student’s t-test. All full blot images were provided in Supplementary File (Figure S3).