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. 2021 May 26;19:156. doi: 10.1186/s12951-021-00900-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — K3-HBc/CLT alleviated tubular cell senescence in vitro and in vivo. A Predominant biological process analyses of differentially expressed genes using GO enrichment. B The p53 signaling pathways roadmap and the related genes of cell cycle and cell senescence. C Heatmaps of the most differentially expressed genes in Sham, UUO, CLT and K3-HBc/CLT groups. D Representative renal SA-β-gal staining in sham, UUO, UUO + CLT and UUO + K3-HBc/CLT mice. Scale bar, 50 μm. E Percentage of SA-β-gal positive area in four groups. F Representative micrographs of the expression and distribution of p21^Cip1 and p16^Ink4a in the kidney sections using immunohistochemical staining and the semi-quantitative IOD analyses of (G) p21^Cip1 and (H) p16^Ink4a after different treatments as indicated (n = 3). Scale bar, 100 μm (**p < 0.01, ***p < 0.001)