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. 2021 May 26;21:616. doi: 10.1186/s12885-021-08308-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Common DEGs PPI network was constructed using the STRING online database and Cytoscape software. a There were 137 nodes and 254 edges in the PPI network. The nodes represent proteins; the edges represent the interaction between proteins; green circles represent downregulated DEGs, and red circles represent upregulated DEGs. b Modular analysis via MCODE (degree cutoff = 2, max. Depth = 100, k-core = 2, and node score cutoff = 0.2). In total, 17 central nodes were screened. Circle size represents node degree, and label font size represents betweenness centrality