Table 2.
Gene Ontology analysis of differentially expressed genes in lung adenocarcinoma
| Expression | Category | Term | Count | % | p-Value | FDR |
|---|---|---|---|---|---|---|
| Downregulated | GOTERM_BP_DIRECT | GO:0001525 ~ angiogenesis | 10 | 6.2 | 3.06E-07 | 4.71E-04 |
| GOTERM_BP_DIRECT | GO:0001570 ~ vasculogenesis | 7 | 4.3 | 3.34E-06 | 0.005135 | |
| GOTERM_BP_DIRECT | GO:0007165 ~ signal transduction | 12 | 7.4 | 1.26E-04 | 0.193754 | |
| GOTERM_BP_DIRECT | GO:0031623 ~ receptor internalization | 5 | 3.1 | 1.45E-04 | 0.222577 | |
| GOTERM_BP_DIRECT | GO:0001755 ~ neural crest cell migration | 5 | 3.1 | 3.69E-04 | 0.566138 | |
| GOTERM_CC_DIRECT | GO:0016021 ~ integral component of membrane | 49 | 30.3 | 1.48E-04 | 0.16707 | |
| GOTERM_CC_DIRECT | GO:0005886 ~ plasma membrane | 25 | 15.4 | 8.82E-04 | 0.993318 | |
| GOTERM_CC_DIRECT | GO:0005578 ~ proteinaceous extracellular matrix | 6 | 3.7 | 0.008111 | 8.80424 | |
| GOTERM_CC_DIRECT | GO:0005911 ~ cell-cell junction | 4 | 2.5 | 0.047922 | 42.63677 | |
| GOTERM_MF_DIRECT | GO:0030215 ~ semaphorin receptor binding | 4 | 2.5 | 2.31E-04 | 0.280668 | |
| GOTERM_MF_DIRECT | GO:0045499 ~ chemorepellent activity | 4 | 2.5 | 8.56E-04 | 1.037711 | |
| GOTERM_MF_DIRECT | GO:0008201 ~ heparin binding | 4 | 2.5 | 0.040365 | 39.47803 | |
| Upregulated | GOTERM_BP_DIRECT | GO:0030574 ~ collagen catabolic process | 3 | 11.1 | 0.003145 | 3.886365 |
| GOTERM_BP_DIRECT | GO:0006508 ~ proteolysis | 5 | 18.5 | 0.003709 | 4.568267 | |
| GOTERM_BP_DIRECT | GO:0007605 ~ sensory perception of sound | 3 | 11.1 | 0.012967 | 15.14675 | |
| GOTERM_BP_DIRECT | GO:0048701 ~ embryonic cranial skeleton morphogenesis | 2 | 7.4 | 0.039861 | 40.06517 | |
| GOTERM_CC_DIRECT | GO:0005615 ~ extracellular space | 8 | 29.6 | 0.001014 | 0.992618 | |
| GOTERM_CC_DIRECT | GO:0005576 ~ extracellular region | 8 | 29.6 | 0.002863 | 2.780239 | |
| GOTERM_CC_DIRECT | GO:0070062 ~ extracellular exosome | 9 | 33.3 | 0.017782 | 16.17818 | |
| GOTERM_CC_DIRECT | GO:0005578 ~ proteinaceous extracellular matrix | 3 | 11.1 | 0.044503 | 36.09452 | |
| GOTERM_MF_DIRECT | GO:0004866 ~ endopeptidase inhibitor activity | 3 | 11.1 | 0.001227 | 1.243792 | |
| GOTERM_MF_DIRECT | GO:0004252 ~ serine-type endopeptidase activity | 4 | 14.8 | 0.004242 | 4.240205 | |
| GOTERM_MF_DIRECT | GO:0004867 ~ serine-type endopeptidase inhibitor activity | 3 | 11.1 | 0.007004 | 6.913304 |