Table 1.
TET2 and DNMT3A mutation status in cancer cell lines
| Cell line | DNMT3A | TET2 | ||
|---|---|---|---|---|
| Mutation status; typea | Nucleotide; protein | Mutation status; type | Nucleotide; protein | |
| ACHN | Missense; deleterious | c.2069T > C; p.V690A | Missense; deleterious | c.1088C > T; p.P363L |
| Missense; deleterious | c.5162T > G; p.L1721W | |||
| BT549 | Missense; deleterious | c.2587G > A; p.E863K | Missense; deleterious | c.1064G > A; p.G355D |
| Missense; deleterious | c.4117G > A; p.A1373T | |||
| SKMEL5 | Missense | c.736G > T; p.A246S | Missense; deleterious | c.1430C > T; p.S477F |
| NCI-H23 | Nonsense | c.667G > T; p.G223X | Missense; deleterious | c.5162T > G; p.L1721W |
| SKMEL2 | Wildtypeb | – | Missense; deleterious | c.5162T > G; p.L1721W |
| DU145 | Wildtype | – | Missense; deleterious | c.5162T > G; p.L1721W |
| KM12 | Missense; deleterious | c.2283G > A; p.M761I | Missense | c.5284A > G; p.I1762V |
| OVCAR3 | Wildtype | – | Wildtype | – |
| COLO205 | Wildtype | – | Wildtype | – |
| MDA231 | Wildtype | – | Missense; deleterious | c.5162T > G; p.L1721W |
| MCF7 | Wildtype | – | Missense; deleterious | c.86C > G; p. P29R |
| M14 | Wildtype | – | Wildtype | – |
| EKVX | Missense; deleterious | c.2375G > A; p.R792H | Missense | c.5284A > G; p.I1762V |
| T47D | Wildtype | – | Missense; deleterious | c.5162T > G; p.L1721W |
| SKOV3 | Wildtype | – | Wildtype | – |
| HCT116 | Wildtype | – | Missense | c.5284A > G; p.I1762V |
| HCT15 | Missense; deleterious | c.2283G > A; p.M761I | Missense | c.5284A > G; p.I1762V |
aPredicted by SIFT (sorting intolerant from tolerant) and/or PolyPhen (polymorphism phenotyping)
bWildtype also refers to the synonymous variants