. 2021 May 26;14:83. doi: 10.1186/s13045-021-01091-5

Table 2.

Modulation of TET2, DNMT3A and p21 by T-dCyd (4 mg/kg) treatment in vivo

Target, mean ± SD	Saline^a	T-dCyd
Target, mean ± SD	Saline^a	C1D5	P value^b	C3D5^c	P value^b
TET2	42.7 ± 3.0	17.3 ± 6.7	< 0.0001	12.8 ± 6.0	< 0.0001
DNMT3A	13.0 ± 2.1	21.8 ± 6.7	0.02	10.6 ± 7.5	0.52
p21	8.7 ± 3.3	68.4 ± 12.2	0.0003	85.9 ± 6.1	< 0.0001

^aImmunohistochemistry data from saline-treated samples at C1D1 were used and shown since p21, DNMT3A and TET2 immunohistochemistry results were similar at C1D1 and C3D5 by saline treatment

^bCompared to saline group by unpaired t test

^cThere were five instead of 6 tumor samples available for analyses of TET2 and DNMT3A at C3D5. C,

cycle, D, day