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. 2021 May 26;9:122. doi: 10.1186/s40168-021-01071-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Longitudinal analyses of the gut microbiota of AOM/DSS mice treated with PP*-P8. a Changes in alpha diversity indices of microbial communities in the fecal samples. Species richness and evenness are plotted as the number of observed ASVs and inverse Simpson and Shannon indices. b Principal coordinate analysis based on Bray-Curtis dissimilarity. Each dot indicates a single sample and each group is shown in a different color. P values correspond to the permutational multivariate analysis of variance results. c Microbial composition at the family level is shown as relative abundance. Except for stage 0.5, which shows a single sample, proportions are the averages of five samples. D0, day 0