Table 5.

Univariate and multivariate analysis of prognostic factors for overall survival

Variables	Univariate	Cox model
	Log-rank	p	HR[95%CI]
Age (< 40 vs ≥40)	0.324
Sex (Male vs female)	0.178
ECOG# (1vs 0)	0.023	0.007	1.889 [1.436–2.876]
Smoker	< 0.001	< 0.001	1.996 [1.432–3.443]
Drinker	0.435
Primary site (Hypopharynx vs others)	< 0.001	< 0.001	3.023 [1.764–6.443]
Tumor stage (T4 vs T2 + T3)	< 0.001	< 0.001	3.453 [2.000–7.546]
Neck stage (N+ vs N0)	< 0.001	< 0.001	2.653 [1.546–6.443]
Disease stage (IV vs III)	< 0.001	< 0.001	4.532 [2.335–13.345]
Immunotherapy	0.681	0.232	2.764 [0.887–5.437]
Curative method (surgery vs CRT)	< 0.001	< 0.001	2.213 [1.233–5.432]

# ECOG Eastern Cooperative Oncology Group

* CRT Chemoradiotherapy