TABLE 1.

Effects of clemizole and La3+ salts on canonical transient receptor channels (TRPC3/4/5/6)

Substance	TRPC3	TRPC4	TRPC5	TRPC6
Clemizole	Blocks*	Blocks**	Blocks	Blocks***
Low‐dose La3+	Blocks	Activates	Activates	Blocks
High‐dose La3+	Blocks	Blocks	Blocks	Blocks

^*Clemizole has 8‐fold selectivity of TRPC5 compared to TRPC3 (Richter et al., 2014).

^**Clemizole has 6‐fold selectivity for TRPC5 compared to TRPC4 (Richter et al., 2014).

^***Clemizole has 10‐fold selectivity of TRPC5 compared to TRPC6 (Richter et al., 2014).