Table 4.
Known reproductive pathways significantly enriched in the positional candidate gene list.
| Pathway | Gene Count | Gene Names | Adj. p-Value * |
|---|---|---|---|
| GnRH Signaling | 16 | RAF1, SOS2, ADCY7, CAMK2A, CAMK2D, EGFR, ITPR1, ITPR2, MAPK13, MAPK3, MAPK8, MAP3K1, PLA2G4D, PLA2G4E, PLA2G4B, PLCB4 | 1.2 × 10−3 |
| Progesterone Mediated Oocyte Maturation | 13 | BRAF, RAF1, ADCY7, CDC25A, HSP90AA1, HSP90AB1, MAPK10, MAPK13, MAPK3, MAPK8, PIK3CB, SPDYC, MOS | 5.6 × 10−3 |
| Estrogen Signaling | 17 | FKBP5, RAF1, ADCY7, CREB3L2, ESR2, SOS2, GRM1, HSP90AA1, HSP90AB1, ITPR1, EGFR, ITPR2, MAPK3, OPRM1, PIK3CB, PLCB4, AKT1 | 1.2 × 10−3 |
| Glutamatergic Synapse | 15 | GNG2, ADCY7, GRIA2, GRIN2A, GRIK1, GRM7, GRM1, GLS2, ITPR1, ITPR2, MAPK3, PLA2G4B, PLA2G4E, PLA2G4D, PLCB4 | 7.0 × 10−2 |
| Regulation of Actin Cytoskeleton | 25 | BRAF, MRAS, LIMK2, RAF1, ARHGEF1, CHRM5, CYFIP2, ENAH, FGFR3, ITGA4, ITGA8, ITGAL, ITGB2, MAPK3, MYLPF, PAK2, PAK5, PIK3CB, PDGFC, PDGFRA, PDGFRB, MOS, VAV3, ITG5, ITGB2 | 1.2 × 10−3 |
| Cholinergic Synapse | 17 | AKT1, GNG2, ADCY7, CREB3L2, CAMK2A, CAMK2D, CHRM5, CHRNA3, CHRNB4, CHRNA7, ITPR1, ITPR2, MAPK3, PIK3CB, PLCB4, SLC5A7, KCNQ4 | 9.3 × 10−4 |
| cAMP Signaling | 24 | AKT1, ATP2B3, BRAF, FXYD1, RAF1, RAPGEF4, ADCY7, CREB3L2, CAMK2D, CNGA1, FSHR, GLP1R, GRIA2, GRIN2A, MAPK3, MAPK8, NPR1, OXTR, PIK3CB, PDE4A, VAV3, ORAI1, RELA, ADORA2A, CAMK2A. | 9.6 × 10−4 |
| Calcium Signaling | 26 | ATP2B3, ATP2A1, ORAI1, ORAI3, ADCY7, AGTR1, CAMK2A, CAMK2D, CHRM5, CHRNA7, EGFR, GRPR, GRIN2A, GRM1, ITPR1, ITPR2, ITPKA, LHCGR, OXTR, PLCB4, PLCD1, PHKG2, PDGFRA, PDGFRB, SLC25A4, VDAC2, ADORA2A | 3.6 × 10−5 |
| Focal Adhesion | 25 | AKT1, BRAF, RAF1, SOS2, CAPN2, COL4A3, COL4A5, COL4A6, ITGA4, ITGA8, ITGAB5, KDR, LAMC3, MAPK3, MAPK8, MYLPF, PAK2, PAK5, PIK3CB, PDGFC, PDGFRA, CAV3, PDGFRB, EGFR, VAV3, VWF, ZYX | 5.6 × 10−4 |
| PI3K-Akt Signaling | 40 | AKT1, CD19, GNG2, RBL2, RELA, RAF1, SOS2, CREB3L2, CASP9, CDC37, COL4A3, COL4A5, COL4A6, CSF1, CSF1R, CDK6, CDKN1A, EGFR, FGF19, FGFR3, GHR, HSP90AA1, HSP90AB1, ITGA4, ITGA8, ITGB5, IL7, KDR, LAMC3, LPAR1, LPAR3, MAPK3, PIK3CB, PDGFC, PDGFRA, PDGFRB, PPP2R5E, PPP2R2C, TSC1, VWF | 1.6 × 10−3 |
| Ovarian Steroidogenesis | 10 | HSD17B7, ADCY7, ALOX5, CYP11A1, CYP1A1, FSHR, LHCGR, PLA2G4B, PLA2G4D, PLA2G4E | 4.2 × 10−3 |
* Adj. p-value: p-value adjusted using FDR.