Table III.

Clinical data for the patients carrying pathogenic variations as predicted in silico

Variation	Patient ID	Age, yr (sex)	Age at onset (yr)	Family history	Clinical features	Response to L-DOPA
c. 101A>G (p.Q34R)	PD-41	52 (males)	48	No	Tremor on left side of the body, rigidity, masked face, postural instability	Yes
	PD-48	45 (females)	43	No	Tremor in both hands, severe headache, bradykinesia	Yes
	PD-111	35 (males)	33	No	Tremor in whole body, rigidity, postural instability, depression	No
	PD-139	65 (male)	60	No	Tremor started on left hand, then spread over whole body, facial tremor, speech disability, postural instability, dementia	Yes
	PD-141	47 (females)	45	No	Tremor in both hands and legs, rigidity, bradykinesia, postural instability	No
c. 125G>A (p.R42H)	PD-75	55 (female)	53	No	Tremor in whole body, bradykinesia, rigidity, postural instability, nausea and vomiting	Yes
c. 245C>A (p.A82E)	PD-76	55 (males)	54	No	Tremor in both hands and legs, bradykinesia, postural instability	Yes
c. 1076G>A (p.G359D)	PD-112	53 (male)	51	No	Tremor on the left side of the body, speech disability, problem in swallowing food, bradykinesia	No
	PD-116	60 (females)	57	No	Tremor in both hands, bradykinesia, postural instability	Yes