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. Author manuscript; available in PMC: 2021 May 27.
Published in final edited form as: Leuk Res. 2015 Apr 17;39(7):684–688. doi: 10.1016/j.leukres.2015.04.004

Table 2.

2008 IWG-MRT diagnostic criteria for post-PV/ET MF [16].

Required criteria Additional criteria (1) Documentation of a previous diagnosis of ET or PV as defined by WHO criteria
(2) Bone marrow fibrosis grade 2/3 (on a 0–3 scale or grade 3/4 (on a 0–4 scale)
Additional criteria Post-PV MF (1) Anemia or sustained loss of requirement for either phlebotomy or for cytoreductive treatment
(2) Leukoerthryoblastic peripheral blood smear
(3) Increasing splenomegaly of ≥5 cm (distance of the tip of the spleen from the left costal margin) or appearance of new splenomegaly
(4) Development of ≥1 of 3 constitutional symptoms: >10% weight loss, night sweats, or unexplained fever >37.5 °C
Post-ET MF (1) Anemia and a 2 mg/ml decrease from baseline hemoglobin level
(2) Leukoerythroblastic peripheral blood smear
(3) Increasing splenomegaly of ≥5 cm (distance of the tip of the spleen from the left costal margin) or appearance of new splenomegaly
(4) Increased lactate dehydrogenase (above reference level)
(5) Development of ≥1 of 3 constitutional symptoms: >10% weight loss, night sweats, or unexplained fever >37.5 °C

Diagnosis requires presence of required criteria and 2 additional criteria.