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Positive predictive value (PPV) of PSA testing for clinically significant prostate cancer using top 5% (PPV95) and top 20% (PPV80) cutoffs of PHS166 and PHS46 risk scores. The percent change for each metric is calculated using the value of PHS46 as the reference.
| PPV | PHS46 | PHS166 | Change (%) |
|---|---|---|---|
| PPV95 | 0.227 [0.159,0.292] | 0.239 [0.171,0.305] | 6.3 [−25.5,32.1] |
| PPV80 | 0.192 [0.155,0.231] | 0.187 [0.150,0.222] | −2.8 [−16.3,9.9] |
