Table 4.

Association of AKI with OS adjusting for the other covariates in a joint model

Parameter	Category	AKI Definition 1a						AKI Definition 1b
		Post Mean	Std Dev	Std Err	2.50%	97.50%	P-Value	Post Mean	Std Dev	Std Err	2.50%	97.50%	P-Value
Age in Yrs	Per year increase	−0.0046	0.0032	0.0001	−0.0116	0.0010	0.126	−0.0044	0.0031	0.0001	−0.0108	0.0014	0.138
Gender	Male vs Female	0.0156	0.0853	0.0025	−0.1579	0.1858	0.874	0.014	0.0824	0.0023	−0.1488	0.1847	0.848
Race (ref = ’Other’)	Black or African American	−0.2667	0.647	0.0177	−1.6108	0.9449	0.692	−0.3274	0.6727	0.0194	−1.7553	0.9434	0.628
	White or Caucasian	−0.4191	0.3824	0.0139	−1.0866	0.4315	0.282	−0.4567	0.3816	0.0161	−1.1265	0.3686	0.244
Drug (ref = ’atezolizumab’)	Ipilimumab	−0.1381	0.4167	0.0133	−0.873	0.7266	0.734	−0.1451	0.4096	0.016	−0.8678	0.7216	0.674
	Ipilimumab/nivolumab	−0.3717	0.4245	0.0179	−1.134	0.4830	0.412	−0.3924	0.4129	0.0149	−1.1317	0.4698	0.344
	Ipilimumab/pembrolizumab	−0.8383	0.4202	0.018	−1.6116	0.0390	0.06	−0.863	0.4151	0.017	−1.6253	0.0442	0.058
	Nivolumab	−0.4012	0.4296	0.0198	−1.2162	0.4397	0.36	−0.4133	0.4118	0.0138	−1.1481	0.4340	0.322
	Pembrolizumab	−0.404	0.4199	0.0153	−1.1568	0.4515	0.352	−0.4226	0.4046	0.0148	−1.1122	0.4361	0.322
PPI (ref = ’No’)	Yes	0.8643	0.1083	0.0017	0.6704	1.0846	<0.0001	0.8716	0.1071	0.0036	0.6672	1.0842	<0.0001
AKI	Per unit increase	−0.0595	0.0435	0.0065	−0.1526	0.0184	0.14	−0.1067	0.0839	0.0196	−0.3079	0.0233	0.12