Table 2.
List of peptides checked for CTL induction
| mutated Peptide |
Wild-type peptide |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Minigene | gene | Amino acid substitution |
Sequence | Affinity to HLA-A (IC50 nM) | Sequence | Affinity to HLA-A (IC50 nM) | tumor_var (RNA) |
mutation ratio |
HLA Alleles |
| B8-3 | PTK7 | D463N | MLISENSRFEV | 31 | MLISEDSRFEV | 44 | 103 | 29% | A*02: 01 |
| NUP214 | P1463S | SLPTSFPTL | 41 | PLPTSFPTL | 4229 | 53 | 24% | A*02: 01 | |
| MAPK13 | G137V | YLVYQMLKV | 9 | YLVYQMLKG | 5484 | 50 | 28% | A*02: 01 | |
| KIF23 | S334 F | ITISQLFLV | 11 | ITISQLSLV | 106 | 32 | 27% | A*02: 01 | |
| MTHFD1L | V418I | VLIAGITPT | 31 | VLVAGITPT | 139 | 31 | 67% | A*02: 01 | |
| MYADM | S68F | FMFTWCFCF | 15 | SMFTWCFCF | 135 | 22 | 15% | A*02: 01 | |
| NID1 | G495E | GIIEWMFAV | 3 | GIIGWMFAV | 4 | 17 | 37% | A*02: 01 | |
| KIAA1429 | D1358E | FLAEHEYGL | 3 | FLAEHDYGL | 3 | 16 | 25% | A*02: 01 | |
| PAQR7 | S119 F | YLFFSALAHL | 8 | YLSFSALAHL | 15 | 15 | 17% | A*02: 01 | |
| LIG3 | G76R | YLVFLPRLHV | 35 | YLVFLPGLHV | 29 | 11 | 15% | A*02: 01 | |