Figure 6.

Proposed mechanism by which A. muciniphila ameliorates MAFLD in HFC diet-induced obese mice. A. muciniphila treatment increases L-aspartate levels in the gut-liver axis, which activates the LKB1-AMPK axis and increases lipid oxidation and bile acid metabolism in the gut-liver axis, leading to decreased lipid accumulation and oxidation stress-induced cell apoptosis. These metabolic improvements result in maintaining the integrity of the gut barrier and reshaping the gut microbiota composition for MAFLD treatment in mice

revised 6