Table 1.

Intercorrelation between the investigated immune markers in the entire cohort

	PT pre-NAC					PT post-NAC					LN metastasis post-NAC
	CD8+	FoxP3+	CD20+	PD-L1IC	PD-L1TC	CD8+	FoxP3+	CD20+	PD-L1IC	PD-L1TC	CD8+	FoxP3+	CD20+	PD-L1IC	PD-L1TC
CD8+
R		0.247	0.509	0.100	0.194		0.292	0.273	0.248	0.292		0.491	0.520	0.143	0.163
p		0.019	<0.001	0.349	0.068		0.005	0.009	0.015	0.004		0.004	0.002	0.469	0.391
n		89	89	89	89		90	91	96	96		33	32	28	30
FoxP3+
R	0.247		0.135	0.395	0.237	0.292		0.351	0.310	0.029	0.491		0.508	0.314	−0.188
p	0.019		0.206	<0.001	0.025	0.005		0.001	0.002	0.783	0.004		0.005	0.092	0.338
n	89		90	89	89	90		86	93	93	33		29	30	28
CD20+
R	0.509	0.135		0.143	0.236	0.273	0.351		0.310	−0.048	0.520	0.508		0.334	−0.085
p	<0.001	0.206		0.178	0.025	0.009	0.001		0.002	0.643	0.002	0.005		0.061	0.644
n	89	90		90	90	91	86		94	94	32	29		32	32
PD-L1IC
R	0.100	0.395	0.143		0.290	0.248	0.310	0.310		0.092	0.314	0.143	0.334		0.125
p	0.349	<0.001	0.178		0.005	0.015	0.002	0.002		0.355	0.092	0.469	0.061		0.475
n	89	89	90		91	96	93	94		103	30	28	32		35
PD-L1TC
R	0.194	0.237	0.236	0.290		0.292	0.029	−0.048	0.092		0.163	−0.188	−0.085	0.125
p	0.068	0.025	0.025	0.005		0.004	0.783	0.643	0.355		0.391	0.338	0.644	0.475
n	89	89	90	91		96	93	94	103		30	28	32	35

R = Spearman’s correlation coefficient, p = p-value, n = number of cases available for analysis, *significance at the 5% level