Table 2.

mRNA expression of 18 actionable immune genes in IBC versus normal breast

Genes	IBC versus normal breast comparison
	Univariate
	N	Normal (median, log2)	IBC (median, log2)	IBC vs. Normal Breast (log2-ratio)	p-value*
BTLA	118	3.5 (3.22–4.18)	3.54 (2.71–6.43)	0.04	0.946
CD274	118	5.32 (5–5.48)	5.51 (3.23–8.66)	0.19	0.768
CD276	118	5.55 (5.49–5.91)	4.93 (3.52–6.81)	−0.62	0.052
HAVCR2	118	5.94 (5.61–6.55)	7.07 (5.27–9.20)	1.13	7.57E-03
TIGIT	118	3.96 (3.64–4.17)	4.48 (2.91–7.06)	0.52	0.056
TNFRSF18	118	4.59 (3.94–4.72)	4.45 (3.21–8.17)	−0.14	0.958
VSIR	118	8.09 (7.85–8.78)	7.80 (5.66–9.68)	−0.29	0.293
CD27	141	5.42 (4.64–7.06)	6.80 (4.63–12.4)	1.38	2.84E-02
CD40	141	5.33 (5.05–5.97)	6.05 (4.71–9.06)	0.72	3.53E-02
CD70	141	3.32 (3–4.05)	5.55 (4.57–8.73)	2.23	6.82E-04
CTLA4	141	2.26 (2.07–2.32)	4.35 (3.33–6.73)	2.09	6.69E-04
ICOS	141	2.21 (1.99–2.36)	3.76 (2.97–8.44)	1.55	6.82E-04
IDO1	141	4.51 (2.75–6.06)	6.08 (3.11–10.8)	1.57	4.49E-02
LAG3	141	2.14 (1.85–2.31)	3.91 (2.45–7.17)	1.77	6.69E-04
PDCD1	141	2.48 (1.96–3.04)	4.76 (4.01–6.59)	2.28	6.43E-04
TNFRSF4	141	2.15 (1.77–2.42)	3.48 (2.92–3.96)	1.33	6.09E-04
TNFRSF9	141	3.21 (2.17–3.53)	4.80 (2.69–8.43)	1.59	9.35E-04
PVRIG	141	4.65 (4.21–5.43)	5.87 (3.8–10.27)	1.22	6.41E-03

*, Mann-Whitney test