Table 3.
mRNA expression of 18 actionable immune genes in IBC versus non-IBC
| Genes |
mRNA expression levels |
IBC versus non-IBC comparison |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| N | non-IBC (median, log2) | IBC (median, log2) |
Univariate |
Multivariate |
|||||
| N | Odds ratio [95%CI] | p-value* | N | Odds ratio [95%CI] | p-value* | ||||
| BTLA | 306 | 3.32 (2.45–6.31) | 3.54 (2.71–6.43) | 306 | 1.46 [1.12–1.9] | 2.05E-02 | 172 | 1.57 [0.89–2.76] | 0.188 |
| CD274 | 306 | 5.1 (3.06–8.86) | 5.51 (3.23–8.66) | 306 | 1.26 [1.07–1.48] | 2.01E-02 | 172 | 1.68 [1.14–2.47] | 2.86E-02 |
| CD276 | 306 | 5.46 (3.39–7.66) | 4.93 (3.52–6.81) | 306 | 0.62 [0.49–0.79] | 8.38E-04 | 172 | 0.53 [0.33–0.84] | 2.50E-02 |
| HAVCR2 | 306 | 7.03 (4.59–9.24) | 7.07 (5.27–9.2) | 306 | 1.06 [0.83–1.35] | 0.692 | 172 | 1.65 [0.97–2.79] | 0.120 |
| TIGIT | 306 | 4.06 (2.8–7.41) | 4.48 (2.91–7.06) | 306 | 1.44 [1.16–1.80] | 6.64E-03 | 172 | 1.69 [1.05–2.71] | 0.069 |
| TNFRSF18 | 306 | 4.7 (2.92–8.29) | 4.45 (3.21–8.17) | 306 | 0.77 [0.63–0.95] | 4.12E-02 | 172 | 0.75 [0.51–1.09] | 0.198 |
| VSIR | 306 | 7.52 (6.03–8.97) | 7.8 (5.66–9.68) | 306 | 2.02 [1.49–2.74] | 1.41E-04 | 172 | 2.55 [1.36–4.78] | 1.43E-02 |
| CD27 | 389 | 6.49 (4.78–9.76) | 6.8 (4.63–12.41) | 389 | 1.40 [1.19–1.66] | 9.28E-04 | 239 | 1.46 [1.11–1.92] | 2.33E-02 |
| CD40 | 389 | 5.82 (4.19–7.96) | 6.05 (4.71–9.06) | 389 | 1.55 [1.2–1.98] | 4.09E-03 | 239 | 2.09 [1.32–3.32] | 8.76E-03 |
| CD70 | 389 | 5.36 (4.19–7.03) | 5.55 (4.57–8.73) | 389 | 1.71 [1.2–2.44] | 1.26E-02 | 239 | 1.5 [0.82–2.73] | 0.269 |
| CTLA4 | 389 | 4.36 (3.09–5.95) | 4.35 (3.33–6.73) | 389 | 1.08 [0.72–1.62] | 0.757 | 239 | 1.23 [0.66–2.29] | 0.580 |
| ICOS | 389 | 3.81 (3–6.53) | 3.76 (2.97–8.44) | 389 | 1.21 [0.96–1.54] | 0.185 | 239 | 1.3 [0.88–1.93] | 0.274 |
| IDO1 | 389 | 5.5 (2.96–10.88) | 6.08 (3.11–10.76) | 389 | 1.26 [1.12–1.42] | 1.32E-03 | 239 | 1.43 [1.15–1.79] | 7.76E-03 |
| LAG3 | 389 | 3.9 (2.63–6.43) | 3.91 (2.45–7.17) | 389 | 1.26 [0.98–1.62] | 0.132 | 239 | 1.38 [0.92–2.07] | 0.194 |
| PDCD1 | 389 | 4.76 (4–5.72) | 4.76 (4.01–6.59) | 389 | 1.45 [0.84–2.51] | 0.265 | 239 | 0.95 [0.41–2.21] | 0.926 |
| TNFRSF4 | 389 | 3.48 (3.02–4.52) | 3.48 (2.92–3.96) | 389 | 0.24 [0.09–0.63] | 1.30E-02 | 239 | 0.30 [0.07–1.29] | 0.173 |
| TNFRSF9 | 389 | 4.72 (3.28–8.2) | 4.8 (2.69–8.43) | 389 | 1.09 [0.90–1.33] | 0.469 | 239 | 1.14 [0.82–1.57] | 0.524 |
| PVRIG | 389 | 5.67 (3.58–9.61) | 5.87 (3.8–10.27) | 389 | 1.28 [1.08–1.53] | 1.96E-02 | 239 | 1.31 [0.98–1.74] | 0.125 |
*, glm