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Selection of SARS-CoV-2 specific antibodies from site-directed mutagenesis libraries of SARS-CoV-1 binders. (a) Enrichment of scFv antibody binders by phage display (polyclonal phage ELISA). (b) Biolayer interferometry affinity measurements of soluble SARS-CoV-2 RBD (at 400 nM, 200 nM, 100 nM, 50 nM; highest concentration only shown for parental antibodies) binding to immobilized antibody (see Methods). (c) Neutralization of live SARS-CoV-2 virus in Vero E6 cells (IgG format)
