Table 1.
Clinical Characteristics, Drug Resistance Profiles and Molecular Epidemiology Characteristics of 42 CRKP Isolates
| Isolation No | Gender | Age (Years) | Seperation Date (Year) | Outcomea | AMK | DOX | MIN | SMZ/TMP | CZA | TGC | Carbapenemase Genotype | MLST | Virulence Genes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 63 | 2015 | Survive | R | R | R | R | S | S | – | ST722 | fimH, uge |
| 2 | M | 48 | 2017 | Survive | R | S | S | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 3 | M | 54 | 2017 | Die | R | S | S | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 4 | M | 54 | 2017 | Die | R | S | S | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 5 | F | 37 | 2017 | Die | R | S | S | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 6 | M | 63 | 2017 | Die | R | I | R | S | S | I | KPC-2 | ST11 | fimH, uge, ybts |
| 7 | M | 44 | 2017 | Survive | S | R | R | R | R | S | NDM1 | ST35 | fimH, uge, ybts, aeroactin, KfuB |
| 8 | F | 81 | 2017 | Die | R | R | R | R | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 9 | M | 47 | 2017 | Survive | R | S | I | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 10 | M | 29 | 2017 | Survive | S | S | S | R | R | S | NDM1 | ST248 | fimH, uge, ybts, aeroactin, KfuB |
| 11 | M | 59 | 2017 | Survive | S | R | R | R | R | S | NDM1 | ST35 | fimH, uge, ybts, aeroactin |
| 12 | M | 17 days | 2017 | Survive | S | R | R | R | R | R | NDM5 | ST20 | fimH, uge, ybts |
| 13 | M | 27 | 2017 | Die | R | S | S | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 14 | M | 48 | 2017 | Die | R | S | S | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 15 | F | 73 | 2017 | Die | R | R | I | R | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 16 | F | 38 | 2018 | Survive | R | S | S | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 17 | M | 36 | 2018 | Survive | R | S | I | S | S | S | KPC-2 | ST11 | fimH, uge, ybts, rmpA |
| 18 | F | 33 | 2018 | Survive | R | S | I | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 19 | M | 53 | 2018 | Die | R | S | S | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 20 | F | 76 | 2018 | Die | R | S | I | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 21 | F | 74 | 2018 | Die | R | I | R | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 22 | F | 85 | 2019 | Die | R | R | R | R | S | I | KPC-2 | ST11 | fimH, uge, ybts |
| 23 | M | 59 | 2019 | Survive | R | S | S | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 24 | M | 80 | 2019 | Die | R | R | R | R | S | I | KPC-2 | ST11 | fimH, uge, ybts |
| 25 | M | 90 | 2019 | Die | R | S | S | R | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 26 | M | 48 | 2019 | Die | R | S | S | R | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 27 | M | 80 | 2019 | Survive | R | R | R | S | S | S | KPC-2 | ST11 | fimH, uge |
| 28 | M | 50 | 2019 | Die | R | R | R | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 29 | M | 87 | 2019 | Die | R | S | S | R | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 30 | F | 47 | 2019 | Die | R | R | R | S | S | I | KPC-2 | ST11 | fimH, uge, ybts |
| 31 | M | 63 | 2020 | Die | R | R | R | R | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 32 | F | 60 | 2020 | Die | R | R | R | R | S | I | KPC-2 | ST11 | fimH, uge, ybts, rmpA |
| 33 | M | 37 | 2020 | Die | S | R | I | S | S | S | KPC-2 | ST15 | fimH, uge, ybts, KfuB |
| 34 | F | 30 | 2020 | Die | R | R | S | S | S | S | KPC-2 | ST11 | fimH, uge, ybts |
| 35 | M | 47 | 2020 | Survive | S | S | S | S | S | S | KPC-2 | ST15 | fimH, uge, ybts, KfuB |
| 36 | M | 62 | 2020 | Die | S | R | S | S | S | S | KPC-2 | ST15 | fimH, uge, ybts, KfuB |
| 37 | F | 31 | 2020 | Die | S | R | R | S | S | S | KPC-2 | ST15 | uge, ybts, KfuB |
| 38 | M | 88 | 2020 | Survive | S | S | S | S | S | S | KPC-2 | ST15 | fimH, uge, ybts, KfuB |
| 39 | M | 78 | 2020 | Survive | S | R | R | S | S | I | KPC-2 | ST15 | fimH, uge, KfuB |
| 40 | M | 62 | 2020 | Survive | S | R | I | S | S | S | KPC-2 | ST15 | fimH, uge, ybts, KfuB |
| 41 | F | 69 | 2020 | Die | S | R | R | S | S | S | KPC-2 | ST15 | fimH, uge, ybts, KfuB |
| 42 | M | 55 | 2020 | Die | S | R | R | S | S | S | KPC-2 | ST15 | fimH, uge, ybts, KfuB |
Note: aSurvive/die within 30 days.
Abbreviations: AMK, amikacin; DOX, doxycycline; MIN, minocycline; SMZ/TMP, sulfamethoxazole/trimethoprim; CZA, ceftazidime/avibactam; TGC, tigecycline.