Table 4.
Antibody signals to globo-series glycolipids in pre-transplant NHPs
| IgM signal |
IgG signal |
||||||
|---|---|---|---|---|---|---|---|
| a411 print # | Abbreviation | Description | Biological relevance | Median | SD | Median | SD |
| 108 | Forssman Di - 21 | GalNAca1–3GalNAcb1-BSA | weak [43] | 16.32 | 0.31 | 12.40 | 1.63 |
| 244 | Forssman Tetra-BSA - 05 | GalNAca1–3GalNAcb1–3Gala1–4Galb-BSA | weak [43] | 15.96 | 0.44 | 12.01 | 0.85 |
| 125 | Forssman Di - 31 | GalNAca1–3GalNAcb1-BSA | weak [43] | 15.87 | 0.52 | 12.29 | 1.61 |
| 119 | Forssman Di - 04 | GalNAca1–3GalNAcb1-BSA | weak [43] | 15.85 | 0.56 | 12.00 | 1.27 |
| 289 | Forssman Tetra-BSA - 13 | GalNAca1–3GalNAcb1–3Gala1–4Galb-BSA | weak [43] | 15.60 | 0.43 | 12.00 | 0.76 |
| 42 | Gb3– 13 | Gala1–4Galb1–4Glc-HSA | strong [44] | 14.60 | 0.67 | 10.40 | 1.48 |
| 254 | Gb4 tetra (P1 tetra)-Sp - 15 | GalNAcb1–3Gala1–4Galb1–4GlcNAcb-Sp-BSA | NA | 14.44 | 1.55 | 10.89 | 1.12 |
| 87 | Gb4 tetra (P1 tetra)-Sp - 06 | GalNAcb1–3Gala1–4Galb1–4GlcNAcb-Sp-BSA | NA | 13.69 | 1.84 | 10.28 | 1.13 |
| 294 | Globo A - 09 | GalNAca1–3(Fuca1–2)Galb1–3GalNAcb1–3Gala1–4Galb1-BSA | possible [45] | 13.64 | 1.92 | 9.33 | 1.36 |
| 241 | SSEA-4-Sp - 12 | Neu5Aca2–3Galb1–3GalNAcb1–3Gala1–4Galb1–4Glcb-Sp-BSA | strong [34] | 13.50 | 2.32 | 9.52 | 1.73 |
| 305 | Gb5/SSEA3 – 12 | Galb1–3GalNAcb1–3Gala1–4Galb1-BSA | possible [35] | 12.65 | 1.61 | 8.89 | 1.10 |
| 231 | SSEA-4-Sp - 05 | Neu5Aca2–3Galb1–3GalNAcb1–3Gala1–4Galb1–4Glcb-Sp-BSA | strong [34] | 12.41 | 2.14 | 8.75 | 1.35 |
| 110 | Globo H - 03 | Fuca1–2Galb1–3GalNAcb1–3Gala1–4Galb1-BSA | possible [45] | 10.56 | 1.00 | 7.94 | 0.57 |
| 112 | Globo B - 12 | Gala1–3(Fuca1–2)Galb1–3GalNAcb1–3Gala1–4Galb1-BSA | possible [45] | 10.52 | 1.67 | 7.95 | 0.65 |
| 291 | Gb5/SSEA3 – 04 | Galb1–3GalNAcb1–3Gala1–4Galb1-BSA | possible [35] | 10.49 | 2.08 | 7.43 | 1.07 |
| 94 | Globo A - 03 | GalNAca1–3(Fuca1–2)Galb1–3GalNAcb1–3Gala1–4Galb1-BSA | possible [45] | 10.39 | 2.09 | 7.32 | 0.88 |
| 81 | Gb4 – 09 | GalNAcb1–3Gala1–4Galb1-BSA | strong [44] | 10.34 | 1.25 | 8.02 | 0.45 |
| 293 | Globo H - 10 | Fuca1–2Galb1–3GalNAcb1–3Gala1–4Galb1-BSA | possible [45] | 10.31 | 2.11 | 7.49 | 1.26 |
| 106 | Globo B - 05 | Gala1–3(Fuca1–2)Galb1–3GalNAcb1–3Gala1–4Galb1-BSA | possible [45] | 9.90 | 0.66 | 7.52 | 0.26 |
Biological relevance is stated high when it is reported that the antigen is expressed on wild type or gene modified porcine cells/tissues. Biological relevance is stated possible when it is reported that the antigen is expressed on mammalian cells/tissues. Biological relevance is stated weak when it is reported that the antigen is not expressed on porcine cells/tissues. Numbers in brackets show reference. NA data not available, NHP nonhuman primate