Table 1.
Summary of systematic reviews and meta-analyses a on the relationship between inflammation and stress-related psychopathology.
| Disorder/Condition | Reference (Year) | # of Studies/Cases | CRP | TNF | IL-1b | IL-6 | IFNg | Others |
|---|---|---|---|---|---|---|---|---|
| Depression | Osimo et. al. 2020 | 107/5166 | ↑ | ↑ | - | ↑ | - | ↑ IL-3, IL-18, sIL-2R |
| Bipolar Disorder | Dargel et. al. 2015 | 11 | ↑ | NA | NA | NA | NA | NA |
| Modabbernia et. al. 2013 | 30/1351 | NA | ↑ | - | ↑ | - | ↑ sIL-2R, sIL-6R, IL-4, IL-10, sTNFR1 | |
| Anxiety, Traumatic Stress | Renna et al. 2018 | 41/1077 | - | ↑ | ↑ | ↑ | - | NA |
| PTSD | Yang et. al. 2020 | 42/1887 | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ IL-2; ↑ leukocytes |
| Generalized Anxiety Disorder | Costello et al. 2019 | 14/1188 | ↑ | NA | NA | NA | NA | NA |
| Panic Disorder | Quagliato et. al. 2018 | 11/887 | NA | - | ↑ | ↑ | - | ↑ IL-5 |
| Obsessive Compulsive Disorder | Cosco et al. 2019 | 16/538 | NA | - | - | - | - | NA |
NA - Not assessed; - denotes null finding; ↑ denotes significantly higher in cases compared to healthy controls