Table 2.

The five most widely observed variants and their predicted fitness. Occurrences refer to their number of occurrences in the GISAID database [46], ${\varphi }_i^{\mathrm{S}}$, ${\varphi }_i^{\mathrm{ACE}2}$, and ${\varphi }_i^{\mathrm{nAb}}$ to the fitness contributions of the variants i related to the stability of the spike protein, its binding affinity for ACE2 and its escape propensity from the host’s immune system, respectively, and ${\Phi }_i$ to the total fitness.

Variants	Occurrences	${\mathit{\varphi }}_{\mathit{i}}^{\mathit{S}}$	${\mathit{\varphi }}_{\mathit{i}}^{\mathbf{ACE}2}$	${\mathit{\varphi }}_{\mathit{i}}^{\mathbf{nAb}}$	${\mathbf{\Phi }}_{\mathit{i}}$
D614G	96%	3.7	1.0	1.0	3.7
A222V	19%	2.0	1.0	1.0	2.0
P681H	19%	1.6	1.0	1.0	1.6
N501Y	18%	2.1	1.4	1.0	2.9