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. 2021 May 13;11:673340. doi: 10.3389/fonc.2021.673340

Figure 1.

Figure 1

The possible mechanisms of doxorubicin-induced chemobrain. (A) Doxorubicin can cross the blood-brain barrier through vascular-associated apical projections of neural stem cells. (B) Oxidative Stress Ptahway. (C) Synaptic dysplasia. (D) TNF-α is involoved in neurotransmitter pathways. (E) TNF-α is involved in oxidative stress pathways. (F) TNF-α amplifies inflammatory signals by activating glial cells.