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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Nature. 2020 Oct 26;592(7852):116–121. doi: 10.1038/s41586-020-2895-3

Figure 4. D614G substitution affects the neutralization susceptibility of SARS-CoV-2.

Figure 4.

(a) Neutralizing activities of hamster sera against D614 and G614 mNeonGreen reporter SARS-CoV-2. Sera from D614 virus-infected hamsters (n=8) were tested for neutralizing titers against D614 and G614 reporter SARS-CoV-2, and the 1/NT50 values are plotted. Symbols represent sera from individual animals. (b) Ratio of 1/NT50 between D614 and G614 viruses. Symbols represent sera from individual animals (n=8), the midline represents the mean, and error bars represent standard deviation. (c) Representative neutralizing curve of hamster serum 5. Symbols represent individual replicates, the solid line represents the fitted curve, and the dotted line indicates 50% viral inhibition. (d) Neutralizing activities of eleven human mAbs against D614 and G614 mNeonGreen SARS-CoV-2. Symbols represent individual mAbs. The data represents one of the two independent experiments. (e) Ratio of NT50 between D614 and G614 viruses. The averages of the NT50 ratios from two independent experiments performed in duplicates are shown. Symbols represent individual mAbs, the midline represents the mean, and the error bars represent the standard deviation. (f) Representative neutralizing curve of mAb18. Symbols represent individual replicates, the solid line represents the fitted curve, and the dotted line indicates 50% viral inhibition.