Extended Data Figure 1. Experimental design of hamster infection and sample harvest.

(a) Graphical overview of experiment to assess the impact of G614 mutation on replication in the respiratory system of hamsters. (b) Schematic organs harvested from hamsters sacrificed on days 2, 4, and 7 post-infection. Illustration of hamster lung adapted from Reznik, G. et al. Clinical anatomy of the European hamster. Cricetuscricetus, L., For sale by the Supt of Docs, U.S. Govt. Print. Off., 1978.