Table 3.
In vitro COX1, COX2 and 5LOX inhibitory activity (IC50) of compounds 4c, 4d, 6a, 6c, 6d and 6e.
| Compound | COX 1 IC50 (µM) | COX 2 IC50 (µM) |
SI | 5LOX IC50 |
|---|---|---|---|---|
| (µM) | ||||
| 4c | 19.88 ± 1.03 | 3.279 ± 0.16 | 6.06 | 8.136 ± 0.5 |
| 4d | 5.824 ± 0.3 | 23.4 ± 1.13 | 0.25 | 16.47 ± 1 |
| 6a | 20.91 ± 1.09 | 1.103 ± 0.05 | 19 | 6.126 ± 0.4 |
| 6c | 64.41 ± 3.35 | 8.263 ± 0.4 | 7.79 | 3.186 ± 0.2 |
| 6d | 17.82 ± 0.93 | 102.7 ± 4.97 | 0.17 | 9.877 ± 0.6 |
| 6e | 12.73 ± 0.66 | 1.714 ± 0.08 | 7.43 | 54.15 ± 3.2 |
| Celecoxib | 35.8 ± 1.25 | 0.204 ± 0.06 | 175.49 | 89.4 ± 1.16 |
| NDGA | na | na | na | 2.96 ± 0.2 |