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. 2021 May 13;12:673763. doi: 10.3389/fimmu.2021.673763

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Copyright © 2021 Dhanushkodi, Srivastava, Coulon, Prakash, Roy, Bagnol, David and BenMohamed

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of FGF-1 on cytokine secretion by human monocyte-derived M1 and M2 macrophages: Unpolarized M0 macrophages were generated from M-CSF-stimulated primary monocytes and then treated with FGF-1 (0.5 and 3 ng/ml) for 24 hr. M1- and M2-polarized macrophages were then generated by stimulation with IFN-γ and IL-4, respectively. (A) M1 signature cytokine (IFN-γ, IL-1α, IL-1β, IL-2, IL-5, IL-12p40, IL-12p70, IL-15, IL-17α, IP-10, TNF-α), levels in the culture supernatants of M1 macrophage treated with FGF-1 and M2 signature cytokine (IL-4, Il-10, VEGF-α) levels in the culture supernatants of M2 macrophage treated with FGF-1. (B) Correlation graph showing level of M1 cytokines with FGF-1 dose kinetics. (IL-1α, IL-1β, IL-12p40, IL-12p70, IL-15, Il-17α, TNF-α, CCL5). (C) Correlation graph showing level of M2 cytokines with FGF-1 dose kinetics (IL-10, VEGF-α).