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. 2021 May 12;12:639049. doi: 10.3389/fimmu.2021.639049

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Copyright © 2021 Wang, Yang, Hou, Xu, Yun, Qin and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BAFF induced microglial training in vivo. Immunofluorescence staining of Iba1 in the cortex (A) and hippocampus (C). Comparisons of the numbers of Iba1-positive microglia in the cortex (B) and hippocampus (D) (n = 6). A representative Iba-1+ cell from the cortex is shown magnified in the red box in the image’s right upper corner. The expression of TNF-α (E), IL-6 (F), CCL2 (G) were measured in the supernatants by ELISA on day 7(n = 6). Data are mean ± SEM; Kruskal-Wallis test with Turkey post hoc test; **p < 0.01, and ***p < 0.001.