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. 2021 May 13;9:659294. doi: 10.3389/fcell.2021.659294

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Copyright © 2021 Zhou, Lu, Xun, Xu, Liu, Xia, Lu, Wang and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TME features of distinct ubiquitin patterns. (A) Tumor purity, immune score, and the stromal score of the subclasses generated by the “ESTIMATE” algorithm. The comparison was performed by Student’s t-test. (B,C) Estimated abundance of 18 adaptive and 10 innate immune cells using ssGSEA. Inter-subgroup comparison was performed by one-way ANOVA. (D) GO enrichment results of pattern B. The Top 20 of biological process (BP), cellular component (CC), and molecular function (MF) were displayed. (E) Association of ubiquitin patterns with immune checkpoint molecules. Kruskal–Wallis test, ns, no statistical difference, * p < 0.05, ** p < 0.01, *** p < 0.001.