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. 2021 May 13;9:659294. doi: 10.3389/fcell.2021.659294

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Copyright © 2021 Zhou, Lu, Xun, Xu, Liu, Xia, Lu, Wang and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation of ubiquitin patterns with immunotherapy benefit. (A,C) The predicted response rate in TIDE analysis of discovery and testing cohorts. Fisher’s exact test, p = 0.008, p < 0.0001, respectively. (B,D) The similarity of gene expression profiles between ubiquitin patterns and melanoma patients treated with ICB (n = 47). CTLA4-noR, patients no respond to anti-CTLA4 treatment, CTLA4-R, patients respond to anti-CTLA4 treatment, PD1-noR, patients no respond to anti-PD1 treatment, PD1-R, patients respond to anti-PD1 treatment.