Fig. 4.
Comparison of cellular infiltration and vascularization into scaffolds. (A–C) Self-assembling peptide hydrogels modulate cellular infiltration into two-component scaffolds and affect implant vascularization. Pristine POC scaffolds had low cellular infiltration and low density of blood vessels (degree of infiltration: scale of 0 refers to no cellular infiltration within the scaffold whereas a scale of 10 refers to complete cellular infiltration throughout the bulk of the scaffold). [POC+SLKr5] scaffolds had high levels of cell infiltration but low vascularization. [POC+SLan] scaffolds had similar cell infiltration as [POC+SLKr5], but had statistically higher vascular ingress, especially at day 28 timepoint (n=4; different Greek letters indicate statistical significance between groups p<0.05). (D) A scheme depicting cellular infiltration and vascularization into microporous scaffolds.