Li 2006.

Study characteristics
Methods	Study design: randomized controlled trial Study grouping: parallel group Loss to follow‐up: not reported Intention‐to‐treat: participants were analyzed in the groups to which they had been assigned Sample size estimation: not reported
Participants	Country: China Setting: ophthalmology center of a teaching hospital Enrollment date: not reported Baseline characteristics Topical mydriatics Number randomized: 46 Mean age, years (SD): 68.8 (NR) Women n (%): 32 (57.1) Race, n (%): Asian, n (%): 46 (100) Preoperative pupillary diameter, mean, mm (SD): not reported Blood pressure, mean (SD): not reported Alpha‐adrenergic agonists, number (%): not reported Pseudoexfoliation syndrome, number (%): 0 Diabetes mellitus, number (%): 0 Pre‐existing cardiac conditions, number (%): not reported Pre‐ and intraoperative NSAIDs at baseline, number (%): not reported Intracameral mydriatics Number randomized: 34 Mean age, years (SD): 69 (NR) Women n (%): 24 (42.9) Race, n (%): Asian, n (%): 34 (100) Preoperative pupillary diameter, mean, mm (SD): not reported Blood pressure, mean (SD): not reported Alpha‐adrenergic agonists, number (%): not reported Pseudoexfoliation syndrome, number (%): 0 Diabetes mellitus, number (%): 0 Pre‐existing cardiac conditions, number (%): not reported Pre‐ and intraoperative NSAIDs at baseline, number (%): not reported Overall Number randomized: 80 Mean age, years (SD): not reported Women n (%): 56 (70) Race, n (%): Asian, n (%): 34 (100) Preoperative pupillary diameter, mean, mm (SD): not reported Blood pressure, mean (SD): not reported Alpha‐adrenergic agonists, number (%): not reported Pseudoexfoliation syndrome, number (%): 0 Diabetes mellitus, number (%): 0 Pre‐existing cardiac conditions, number (%): not reported Pre‐ and intraoperative NSAIDs at baseline, number (%): not reported ("NOTE: Some values published as "SDs" may be "SEs".) Inclusion criteria: continuous cases of phacoemulsification and intraocular lens implantation were performed at the Zhongshan Ophthalmic Center of Sun Yat‐sen University from January 2004 to June 2004. The inclusion criteria included: (1) medium nuclear hardness (II) ~ III grade cataract patients, because of the high risk of hard or hard nuclear phacoemulsification itself, affecting the trial; (2) no glaucoma, uveitis, fundus lesions, and other eye abnormalities; (3) no surgery complications such as uveitis and fulminant choroidal hemorrhage Exclusion criteria: (1) patients with eye abnormalities, such as glaucoma, uveitis, fundus lesion, etc.; (2) patients with complications of surgery origin, such as uveitis, choroidal expulsive hemorrhage Pretreatment: not reported
Interventions	Topical mydriatics: compound tropicamide eyedrops Intracameral mydriatics: 1% hydrochloride lidocaine
Outcomes	Primary: not reported Secondary: not reported Measured outcome: pupillary size at time of capsulorhexis, at the beginning of procedure
Identification	Author name: Xiumei Li Institution: Ophthalmology center of Sun Yat‐sen University Email: zhenpinz@hotmail.com Address: Ophthalmology center of Sun Yat‐sen University, Guangzhou, China 510060 Clinical Trials Registration Number: not reported
Notes	Sponsorship source: not reported Conflict of interest: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Authors mentioned random number generation, but it is unclear how this was generated.
Allocation concealment (selection bias)	Unclear risk	Method of treatment allocation concealment before assignment not reported.
Masking of participants and personnel (performance bias)	Unclear risk	Masking of participants and study personnel not reported.
Masking of outcome assessment (detection bias)	Unclear risk	Masking of outcome assessors not reported.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Participant attrition not reported.
Selective reporting (reporting bias)	Unclear risk	No trial registration; however, while outcomes specified in the methods section were reported in the results section, selective outcome reporting may still exist.