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. 2021 May 18;9(5):569. doi: 10.3390/biomedicines9050569

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Ischemia and reperfusion in isolated perfused heart preparations. (A) Exemplary recordings of the time course of force reduction (ischemia) and force recovery (reperfusion, Rep) in isolated perfused heart preparations from WT and 5-HT₄-TG. The perfusion rate was always 2 mL/min. No flow ischemia indicates global ischemia of the heart by stopping the perfusion pump. Horizontal bar: 20 min of ischemia. A period of 20 min ischemia did not cause permanent damage because, after reperfusion, force (B) and heart rate (C) of both 5-HT₄-TG and WT reached preischemic values again. Time to 50% decline of developed force (F_½) during ischemia was reduced in 5-HT₄-TG compared to WT (D). WT = wild-type mice, 5-HT₄-TG=5-HT₄-transgenic mice. Data shown are means ± SEM. ^# p < 0.05 vs. WT.