Table 4.

Serum metabolites related to amino acid metabolism that were decreased in cats undergoing weight loss.

Metabolic Pathway	Metabolite	Fold Change
		wk 1	wk 2	wk 4	wk 8	wk 12	wk 16
		wk 0	wk 0	wk 0	wk 0	wk 0	wk 0
Amino Acids
Glycine, Serine and Threonine Metabolism	sarcosine (N-Methylglycine)	0.62	0.72	0.61	0.50	0.57	0.53
	threonine	0.95	0.92	0.87	0.82	0.78	0.80
Glutamate Metabolism	glutamate	0.71	0.73	0.82	0.81	0.95	0.67
Lysine Metabolism	glutarate (pentanedioate)	0.75	0.64	0.67	0.61	0.63	0.71
Phenylalanine and Tyrosine Metabolism	N-acetylphenylalanine	0.87	0.81	0.81	0.80	0.77	0.80
	phenyllactate (PLA)	0.70	0.68	0.72	0.74	0.74	0.69
	o-cresol sulfate	0.68	0.49	0.26	0.27	0.36	0.47
	Gentisate	0.79	0.85	0.58	0.72	0.45	0.59
	3-[3-(sulfooxy)phenyl]propanoic acid	0.79	0.86	0.47	0.56	0.47	0.47
	3-(3-hydroxyphenyl)propionate	0.68	0.75	0.45	0.52	0.45	0.48
	3-(4-hydroxyphenyl)propionate	0.45	0.57	0.37	0.32	0.31	0.28
	4-hydroxycinnamate sulfate	0.66	0.69	0.43	0.38	0.31	0.28
Tryptophan Metabolism	N-acetyltryptophan	0.85	0.78	0.76	0.65	0.68	0.70
	indolelactate	0.87	0.87	0.91	0.89	0.87	0.83
	indolepropionate	0.71	0.66	0.64	0.59	0.61	0.56
	picolinate	0.95	0.89	0.72	0.58	0.58	0.48
	indole-3-carboxylic acid	0.82	0.79	0.78	0.53	0.49	0.49
Leucine, Isoleucine and Valine Metabolism	leucine	1.02	1.00	0.98	0.93	0.89	0.95
	2-hydroxy-3-methylvalerate	0.57	0.55	0.60	0.65	0.70	0.66
Methionine, Cysteine, SAM and Taurine Metabolism	methionine	0.91	0.88	0.85	0.76	0.71	0.79
	N-acetylmethionine	0.85	0.83	0.79	0.83	0.80	0.80
	methionine sulfoxide	0.73	0.74	0.71	0.60	0.60	0.69
	S-adenosylhomocysteine (SAH)	0.63	0.56	0.63	0.72	0.46	0.50
	Cystathionine	0.80	0.80	0.79	0.68	0.76	0.76
	hypotaurine	0.31	0.31	0.35	0.41	0.36	0.28
	taurine	0.72	0.72	0.72	0.72	0.68	0.62
	N-acetyltaurine	0.86	0.86	0.82	0.81	0.84	0.74
Urea cycle; Arginine and Proline Metabolism	urea	1.05	0.95	0.93	0.83	0.83	0.79
	citrulline	0.96	0.94	0.98	0.91	0.87	0.85
	N-delta-acetylornithine	0.94	0.89	0.86	0.81	0.77	0.74
	N-methylproline	0.86	0.88	0.80	0.80	0.74	0.80

Numbers in green text were significantly lower than the baseline (wk 0).