Table 6.
Serum metabolites related to nucleotide, xenobiotic, and cofactor and vitamin metabolism that were increased in cats undergoing weight loss.
| Metabolic Pathway | Metabolite | Fold Change | |||||
|---|---|---|---|---|---|---|---|
| wk 1 | wk 2 | wk 4 | wk 8 | wk 12 | wk 16 | ||
| wk 0 | wk 0 | wk 0 | wk 0 | wk 0 | wk 0 | ||
| Nucleotide | |||||||
| Purine Metabolism, Adenine containing | N6-methyladenosine | 1.10 | 1.33 | 1.60 | 1.66 | 1.62 | 1.63 |
| N6-carbamoylthreonyladenosine | 1.02 | 1.12 | 1.27 | 1.36 | 1.30 | 1.22 | |
| 7-methylguanine | 1.08 | 1.06 | 1.07 | 1.06 | 1.11 | 1.12 | |
| Pyrimidine Metabolism, Orotate containing | orotate | 1.10 | 1.08 | 1.17 | 1.26 | 1.38 | 1.20 |
| N4-acetylcytidine | 1.13 | 1.11 | 1.27 | 1.31 | 1.21 | 1.22 | |
| Pyrimidine Metabolism, Thymine containing | 3-aminoisobutyrate | 1.11 | 1.25 | 1.13 | 1.29 | 1.19 | 1.18 |
| Xenobiotics | |||||||
| Food Component/Plant | 4-allylphenol sulfate | 1.05 | 1.06 | 1.14 | 1.28 | 1.32 | 1.44 |
| Chemical | 2-hydroxyisobutyrate | 1.18 | 1.27 | 1.34 | 1.63 | 1.9 | 1.87 |
| Vitamins and Cofactors | |||||||
| Tocopherol Metabolism | alpha-CEHC sulfate | 1.07 | 1.06 | 1.09 | 1.44 | 1.44 | 1.53 |
Numbers in red text were significantly higher than the baseline (wk 0).