Figure 3. DCM genetic architecture spans ten gene ontologies.

19 genes deemed highly clinically relevant (definitive and strong noted in bold; moderate in regular text) for DCM are in the middle ring. The outermost ring lists other high evidence phenotypic associations and the innermost risk provides an ontology classification for each gene, respectively. Of 19 DCM genes, 14 have also been classified as high levels of evidence in HCM, ARVC, LQTS, and/or Brugada Syndrome, except for NEXN, noted with an asterisk, which has limited evidence in HCM. Ontology abbreviations include: SR, sarcoplasmic reticulum; Co-Chap HSP, co-chaperone, heat shock protein. Figure from⁵.