Table 3. Summary of the outcomes comparing various surgical modalities for cardiac sympathetic denervation. The P value represents comparison of the surgical modality to all bilateral surgical cardiac sympathetic denervation. The asterisk indicates values reaching statistical significance or P < .05.
|
SURGICAL MODALITY |
INCLUDED STUDIES (#) |
PATIENTS DENERVATED |
MEAN AGE (YEARS) |
AGE RANGE (YEARS) |
MEAN FOLLOW-UP (YEARS) |
MEAN FOLLOW-UP RANGE (YEARS) |
% MORTALITY/TRANSPLANT (95% CI) |
MORTALITY/TRANSPLANT P VALUE |
% ICD SHOCK-FREE AFTER DENERVATION (95% CI) |
ICD SHOCK-FREE P VALUE |
% ICD SHOCK-/TRANSPLANT-FREE SURVIVAL AFTER DENERVATION (95% CI) |
ICD SHOCK-/TRANSPLANT-FREE SURVIVAL P VALUE |
REFERENCES |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
All bilateral thoracoscopic denervation procedures (baseline) |
12 |
161 |
53.38 |
20 to 80 |
1.24 |
0.19 to 1.9 |
19.3% (13.9-26.0) |
n/a |
59.0% (51.3-66.3) |
n/a |
10,11,14, 16,18,19,21, 23-26,29 |
||
|
Bilateral thoracoscopic denervation with lower half stellectomy T2-T4 ganglionectomy with Kuntz nerve division if identified |
7 |
143 |
53.40 |
20 to 73 |
1.3 |
0.19 to 1.9 |
18.9% (13.3-26.0) |
> .999 |
57.3% (49.1-65.2) |
0.816 |
8,11,19,21,24,26,29 |
||
|
All left thoracoscopic denervation procedures |
9 |
69 |
48.37 |
22 to 80 |
1.7 |
0.52 to 2.75 |
31.9% (22.1-43.6)* |
.042* |
53.6% (42.0-64.9) |
0.47 |
8,12,15,17,22,23,27-29 |