Table 2.

Biomarkers consistently associated with death or relapse.

Variable	HR	Risk of Death 95% CI for HR		p-Value (Bonferroni)
		Lower	Upper
NRAS (wt vs. mut)	1.94	1.21	3.08	0.005 (0.067)
TP53 (wt vs. mut)	2.57	1.76	3.76	9.8 × 10−7 (0.128 × 10−5)
Variable	HR	Risk of Relapse 95% CI for HR		p-Value (Bonferroni)
		Lower	Upper
BCOR (wt vs. mut)	3.60	1.81	7.16	0.000271 (0.004)

Biomarkers identified with an adjusted Cox regression analysis (model; p ≤ 0.05) were included in the table. Cox regression model was adjusted for age, cytogenetic risk group (low–intermediate/high risk, classification ELN 2017), AZA or FLUGA arm, and presence of mutations in any gene included in the panel. Analyses based on 194 patients and 157 events for overall survival, and 194 patients and 124 events for relapse-free survival. Wt: wild-type, mut: mutated, HR: hazard ratio, CI: confidence interval; p-value is adjusted by the Bonferroni criteria in parenthesis.