Figure 8.
Schematic depiction p110 CUX1 effect on EGFR–MEK-ERK signaling. p110 CUX1 synergizes with EGFR-KRASmut signaling by reinforcing MEK-ERK signaling via upregulation of the EGF ligand sheddase ADAM17 and the serine/threonine kinase MOS.
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