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Schematic representation of the heterogeneous microenvironment present in GBM. Astrocytes, GSCgly, and differentiated glioma cells all consume glucose, rely on glycolysis, and release lactate, thus potentially creating areas favorable for GSCmit to switch to lactate as an alternative carbon source (GSCmit->lac) and leading to metabolic cooperation or symbiosis. Created with BioRender.com.
