Figure 1.

Model summarizing the polarization of various cytoskeletal and Ca²⁺ signaling components in a migrating cell. Mature focal adhesions (FA), L-type voltage-gated Ca2+ channels (VGCC), ERM (Ezrin, Radixin and Moesin) proteins, as well as cortical actin (Membrane Proximal Actin (MPA) are enriched at the rear end of the cell. TRPM7 and the plasma membrane Ca²⁺-ATPase (PMCA) are enriched at the leading edge of the migrating cell. Store-operated Ca²⁺ entry (SOCE), which is mediated by STIM1 and Orai1 have been functionally implicated in disassembly of FA at the rear end, as well as in refilling Ca²⁺ stores at the leading edge. See text for further details. The figure was created using BioRender.com.