Table 2.

Effect of modulation of the expression of STIM and Orai isoforms on the migration of different cell lines.

Cell Lines	Method	Result	Ref.
Human embryonic kidney cells (HEK293)	STIM1/Orai1 knockdown	Reduced migration	[92]
Vascular smooth muscle cells (VSMCs)	STIM1/STIM2/Orai1/Orai2/Orai3 knockdown	STIM1/Orai1 reduced migration No effect for STIM2/Orai2/Orai3	[93,94]
Mouse embryonic fibroblasts (MEF)	STIM1 knockout	Enhanced migration	[95]
	STIM1 knockdown	Reduced invasion	[96]
Human umbilical vein endothelial cells (HUVEC)	STIM1 knockdown	Enhanced migration	[24]
	STIM1 overexpression	Decreased migration
Primary human bronchial smooth muscle cells	STIM1/STIM2/Orai1 knockdown	STIM1/Orai1 reduced migration STIM2 no effect	[97]