Table 1.

The chemical structures, α-Glucosidase inhibitory activities, QSAR-predicted activities, and residual values of [α-Glucosidase known Inhibitors (αGIs)] used in QSAR modeling.

αGIs	R1	R2	IC50 (µM)	pIC50	Predicted	Residual
αGI1	H		26.7	4.57	4.46	0.11
αGI2	H		39.8	4.40	4.33	0.07
αGI3	H		96.9	4.01	4.02	−0.01
αGI4	H		20.1	4.69	4.65	0.04
αGI5 *	H		100	4.00	3.83	0.17
αGI6	H		100	4.00	3.88	0.12
αGI7	H		100	4.00	4.07	−0.07
αGI8	H		100	4.00	3.89	0.11
αGI9	OH		60.8	4.21	4.11	0.10
αGI10	H		45.7	4.34	4.35	−0.01
αGI11	OH		96.7	4.01	4.15	−0.14
αGI12	OH		100	4.00	4.09	−0.09
αGI13	OH		95.4	4.02	4.02	0.00
αGI14	OH		86.3	4.06	4.01	0.05
αGI15	H		30.8	4.51	4.29	0.22
αGI16 *	OH		25.2	4.59	4.90	−0.31
α G Is	R		IC50 (µM)	pIC50	Predicted	Residual
αGI17			29.14	4.53	4.99	−0.46
αGI18			7.58	5.12	4.85	0.27
αGI19			1.1	5.95	5.60	0.35
αGI20			4.26	5.37	4.99	0.38
αGI21 *			3.15	5.50	5.01	0.49
αGI22			6.1	5.21	5.00	0.21
αGI23			4.58	5.33	5.35	−0.02
αGI24			16.1	4.79	4.95	−0.16
αGI25 *			36.46	4.43	4.01	0.42
αGI26			24.14	4.61	4.87	−0.26
αGI27			29.14	4.53	4.71	−0.18
αGI28			4.58	5.33	5.08	0.25
αGI29			16.1	4.79	4.70	0.09
αGI30			6.46	5.18	5.06	0.12
αGI31			34.14	4.46	4.64	−0.18
αGI32 *			11.14	4.95	5.09	−0.14
αGI33			10.58	4.97	4.87	0.10
α G Is 34–38
αGI34			133.57	3.87	3.72	0.15
αGI35 *			500	3.30	3.40	−0.10
αGI36			500	3.30	3.68	−0.38
αGI37			68.46	4.16	3.93	0.23
αGI38			61.86	4.20	4.00	0.20

* Test Set Compounds.