Table 2. In Vivo Antimalarial Potential of Selected Compounds against P. y. nigeriensis Multidrug-Resistant P. yoelii-MDR in Albino Mice of Swiss Strain.
| compound no. | dose | % suppression on day 4 post infection | survival on day 28 | cure on day 28 | MST (days) |
|---|---|---|---|---|---|
| 9a | 100 mg/kg × 4 days | 100 | 2/5 | 2/5 cured | 21 |
| 9d | 100 mg/kg × 4 days | 99.99 | 0/5 | 0/5 cured | 9.4 |
| 10c | 100 mg/kg × 4 days | 93.99 | 0/5 | 0/5 cured | 9 |
| 10g | 100 mg/kg × 4 days | 62.30 | 0/5 | 0/5 cured | 7.2 |
| 11b | 100 mg/kg × 4 days | 99.8 | 0/5 | 0/5 cured | 8.8 |
| 11d | 100 mg/kg × 4 days | 99.85 | 0/5 | 0/5 cured | 8.8 |
| α/β-arteether (reference drug) | 7.5 mg/kg × 3 days | 100 | 5/5 | 5/5 cured | >28 |
| control | 0/5 | 0/5 cured | 5.4 |