Table 1. Amphiphilic Peptides and the Measured CAC Values Collected from the Literaturea.
| peptides | CAC (−log M) | refs | peptides | CAC (−log M) | refs | peptides | CAC (−log M) | refs |
|---|---|---|---|---|---|---|---|---|
| V6K2GRGDS | 4.83 | (23) | A10H6 | 6.64 | (31) | Ac-GAVILEE | 3.15 | (38) |
| Ac-A6K± | 4.60 | (24) | RF | 1.74 | (32) | Ac-GAVILEE-NH2 | 3.10 | |
| Ac-L6K2-NH2 | 4.34 | (25) | [RF]2 | 4.40 | Ac-I3D | 2.96 | ||
| Ac-L6K3-NH2 | 3.60 | [RF]3 | 2.64 | Ac-L3D | 2.92 | |||
| Ac-V6K2-NH2 | 3.48 | [RF]4 | 3.52 | Ac-L3K-NH2 | 2.92 | |||
| Ac-V6K3-NH2 | 3.08 | [RF]5 | 4.70 | Ac-V3K-NH2 | 2.80 | |||
| Ac-V3D | 2.64 | |||||||
| Ac-V6K4-NH2 | 2.33 | A6YD | 2.52 | (33) | Ac-V6K-NH2 | 3.35 | (39) | |
| Ac-L6K4-NH2 | 2.27 | V4WD2 | 2.12 | A3C | 3.42 | (40) | ||
| Ac-A6K2-NH2 | 2.10 | V4D | 2.70 | (34) | V3C | 3.77 | ||
| Ac-V6D | 3.30 | (26) | V4WD | 2.32 | I3C | 4.15 | ||
| Ac-V6D2 | 2.96 | I4WD2 | 2.39 | I4K | 3.60 | (41) | ||
| A6RGD | 1.74 | (27) | L4WD2 | 2.72 | I5K | 3.89 | ||
| G3A3V3I3K3 | 3.23 | (28) | RFL4FR | 3.10 | (35) | LI2K | 2.99 | |
| K3I3V3A3G3 | 3.19 | K60L30 | 10.19 | (36) | L4K | 3.27 | ||
| I3V3A3G3K3 | 3.28 | K60L20 | 6.17 | L5K | 3.85 | |||
| K3G3A3V3I3 | 3.55 | E60L20 | 5.46 | Ac-A6D | 3.34 | (42) | ||
| V3G3I3A3K3 | 3.01 | K80L20 | 4.38 | Ac-GAVILRR-NH2 | 3.09 | (43) | ||
| K3A3I3G3V3 | 3.15 | K60L10 | 4.01 | K4X4-gAb | 3.70 | (44) | ||
| K-K8 | 2.10 | (29) | Ac-A9K-NH2 | 4.82 | (37) | K5X3-gA | 3.68 | |
| KK8 | 2.10 | Ac-A6K-NH2b | 3.70 | K8-gA | 3.66 | |||
| IK-K11 | 2.58 | Ac-A3K-NH2 | 2.00 | K6X2-gA | 3.64 | |||
| IKK11 | 2.66 | Ac-A6D | 3.52 | (38) | K7X1-gA | 3.62 | ||
| IK-K16 | 3.03 | DA6-NH2 | 3.70 | K3X5-gA | 3.77 | |||
| IKK16 | 3.13 | KA6-NH2 | 3.52 | |||||
| GAAVILRR | 1.52 | (30) | Ac-I3K-NH2 | 3.35 |
a
The CAC values were measured by fluorimetry,23−36 conductivity,37−41 or dynamic light scattering (DLS) techniques42−44 in pure water. All concentrations are represented as −log M. The defined test set is presented in bold font. Long peptides are indicated by italic format. All peptide structures and molar concentrations can be found in the supporting information Table S4.
b
The value of CAC for Ac-A6K-NH2 was extracted from reference (38) as the techniques used there tended to be more accurate than those used in the other reports.