Table 3. Prognostic factors for 14-days mortality in patients with methicillin-sensitive Staphylococcus aureus bacteremia (N = 338).
| Patient characteristics | 14-days mortality | Univariate analysis | Cox regression | |||
|---|---|---|---|---|---|---|
| Died n = 22 (6) | Survived n = 316 (94) | OR (95% CI) | p-value | HR (95% CI) | p-value | |
| Male sex | 16 (73) | 192 (61) | 1.72 (0.66–4.52) | NS | --- | --- |
| Age > 60 years | 16 (73) | 149 (47) | 2.99 (1.14–7.84) | * | --- | --- |
| Healthy—nonfatal A | 11 (50) | 263 (83) | 0.20 (0.08–0.49) | *** | 0.25 (0.10–0.63) | ** |
| Intensive care unit B | 11 (50) | 44 (14) | 6.78 (2.72–16.9) | *** | 3.24 (1.29–8.11) | * |
| MMP-8 cut-off 203 C | 14 (64) | 125 (39) | 2.67 (1.09–6.56) | * | --- | --- |
| MMP-8 cut-off 239 D | 15 (68) | 88 (28) | 6.99 (2.46–19.8) | *** | --- | --- |
| MMP-8 / TIMP-1 cut-off 0.87 C | 16 (73) | 148 (47) | 3.03 (1.15–7.94) | * | --- | --- |
| MMP-8 / TIMP-1 cut-off 1.02 D | 16 (73) | 101 (32) | 7.60 (2.48–23.3) | *** | 4.71 (1.67–13.3) | ** |
| Endocarditis | 9 (41) | 51 (16) | 3.59 (1.46–8.86) | ** | --- | --- |
* p < 0.05
** p < 0.01
*** p < 0.001 and NS = non-significant.
A McCabe’s classification [38].
B At blood culture collection time-point.
C & D At day 3 and 5 past blood culture collection.
E Adjunctive therapy.
Patients with chronic renal failure were excluded (N = 57) due to low initial MMP-8 concentrations. Values are number of patients (%), odds or hazards ratios (OR or HR) with 95% confidence intervals (95% CI).