Table 3. Results of sensitivity analyses using time in range during the first three days.

		HbA1c <6.5%				HbA1c ≥6.5%
Time in range		Mortality / n	Mortality rate	Unadjusted OR	Adjusted OR*	Mortality / n	Mortality rate	Unadjusted OR	Adjusted OR*
Time in range (threshold at 80%)
	<80%	144 / 491	29%	2.12 (1.56–2.89)	1.88 (1.36–2.61)	67 / 210	32%	0.97 (0.47–2.00)	0.56 (0.23–1.37)
	≥80%	80 / 489	16%	1 (reference)	1 (reference)	13 / 40	33%	1 (reference)	1 (reference)
Time in range (10% incremental category)
	<60%	84 / 261	32%	2.32 (1.57–3.42)	2.02 (1.33–3.06)	56 / 171	33%	1.32 (0.52–3.33)	0.65 (0.21–1.97)
	60%-69%	20 / 92	22%	1.36 (0.77–2.41)	1.16 (0.63–2.14)	4 / 15	27%	0.99 (0.23–4.15)	0.25 (0.05–1.37)
	70%-79%	40 / 138	29%	2.00 (1.25–3.19)	1.90 (1.15–3.13)	7 / 24	29%	1.12 (0.32–3.84)	0.37 (0.08–1.68)
	80%-89%	25 / 165	15%	0.87 (0.52–1.46)	0.88 (0.51–1.51)	6 / 14	43%	2.04 (0.52–8.00)	1.09 (0.20–6.07)
	≥90%	55 / 324	17%	1 (reference)	1 (reference)	7 / 26	27%	1 (reference)	1 (reference)
Time in range (10% decremental)				1.11 (1.05–1.16)	1.09 (1.03–1.15)			1.01 (0.93–1.10)	1.01 (0.91–1.12)
Time in range (quartile category)
	Q1 (<53%)	61 / 187	33%	2.28 (1.42–3.65)	2.07 (1.25–3.43)	50 / 153	33%	1.34 (0.54–3.66)	0.66 (0.21–2.05)
	Q2 (53%-80%)	83 / 304	27%	1.91 (1.27–2.89)	1.61 (1.04–2.50)	17 / 57	30%	1.19 (0.44–3.50)	0.52 (0.15–1.76)
	Q3 (81%-93%)	25 / 165	15%	1.34 (0.90–1.99)	1.52 (0.86–2.01)	6 / 14	43%	1.41 (0.48–4.39)	0.56 (0.15–2.10)
	Q4 (≥94%)	55 / 324	17%	1 (reference)	1 (reference)	7 / 26	27%	1 (reference)	1 (reference)

*Logistic regression adjusted for age, sex, Charlson comorbidity index, APACHE Ⅱ score, and primary diagnosis category (sepsis, cerebrovascular diseases, cardiac diseases, cardiac arrest, respiratory diseases, gastrointestinal diseases, trauma, postoperative, and others).

APACHE, Acute Physiology and Chronic Health Evaluation; HbA1c, glycosylated hemoglobin; OR, odds ratio; CI, confidence interval.