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. 2021 May 27;15(5):e0009374. doi: 10.1371/journal.pntd.0009374

Fig 5. T cell response in mice after immunization with pSARS-S and SARS2-S DNA vaccines.

Fig 5

BALB/c (A-D) and C57BL/6 (E-H) mice (n = 4 per group) were intramuscularly immunized twice at a 3-week interval with 100 μg of vector, pSARS-S or pSARS2-S, followed by electroporation. Splenocytes were collected at week 4 after the first immunization, and the levels of secreted IFN-γ (A, E), IL-2 (B, F), IL-5 (C, G) and IL-13 (D, H) were evaluated after restimulation with recombinant SARS-CoV-2 S protein. Antibody titers are presented as the mean ± SEM. *p<0.05 by the Mann-Whitney test.